Blar i forfatter "Burton, Francis"

Viser treff 1-2 av 2

    • Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology 

      Dietrichs, Erik Sveberg; McGlynn, Karen; Allan, Andrew; Connolly, Adam; Bishop, Martin; Burton, Francis; Kettlewell, Sarah; Myles, Rachel; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-07)
      <i>Aims</i> - Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This <i>in vitro</i> experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in therapeutic and accidental hypothermia.<p><p> <i>Methods and results</i> - Detailed ECG, surface electrogram, and panoramic optical ...

    • Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study 

      Selli, Anders Lund; Ghasemi, Mohammadreza; Watters, Taylor; Burton, Francis; Smith, Godfrey L; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-25)
      Background Accidental hypothermia, recognized by core temperature below 35 °C, is a lethal condition with a mortality rate up to 25%. Hypothermia-induced cardiac dysfunction causing increased total peripheral resistance and reduced cardiac output contributes to the high mortality rate in this patient group. Recent studies, in vivo and in vitro, have suggested levosimendan, milrinone and isoprenaline ...